Are
you
fascinated
by
neurosciences?
This is for you!
Three positions will be open starting from September 2024 focusing on cutting-edge research in molecular neuroscience, computational biology, and clinical translation.
IWe are looking for candidates at various levels of experience, spanning from post-graduate fellows to post-doctoral researchers.
If you’re interested, please contact us!
Our goal is the development and validation of novel therapeutic approaches and pharmacodynamic biomarkers for Motor Neuron Diseases.
in the framework of a project funded by the Department of Defense (ALS Therapeutic Award – Biomarker Option), we aim to validate a novel molecular target that could enable: i) fine-tuning of neuroinflammatory and neuroprotective responses, and ii) assessment of a peripherally accessible biomarker as a potential indicator of disease severity or response to treatment.
While the primary site of work will be the University of Pavia, we are also recruiting at partner institutions such as the IRCCS Carlo Besta Institute in Milan and the Harvard Medical School/Boston Children’s Hospital in Boston, MA, USA. Regardless of the hiring location, candidates will have the chance to travel between these three institutions.
POSITIONS IN DETAILS:
Job descriptions.
The candidates will employ state-of-the-art molecular and computational approaches to investigate epigenomic, transcriptomic, and proteomic alterations at the single-cell level, elucidating the region-specific engagement of neurodegenerative and neuroinflammatory processes in various areas of the Central and Peripheral Nervous System in animal models of ALS and ALS-FTD. Additionally, a proof-of-concept efficacy study will be conducted at the preclinical level in SOD1 and C9Orf72 animal models to validate a novel potential therapeutic approach for ALS.
POSITIONS IN DETAILS:
Position 1
Post-doc position in computational biology/bioinformatics/genomics.
Responsibilities:
– Develop and implement computational methods for analyzing and integrating multi-omics single-cell genomics datasets (e.g., scRNA-seq, scATAC-seq).
– Data Exploration and Visualization
– Collaborate with other team members to integrate statistical insights into the overall project
Qualifications:
– PhD in Computational Biology/Bioinformatics/Statistics/Genomics or PhD in Biological science and strong interest in expanding computational skills
– Proficiency in R and/or Python.
– Familiarity with scRNA-seq data analysis techniques is advantageous.
– Familiarity with statistical/ML methods is advantageous.
– Prior knowledge of neurobiology or related fields is advantageous.
Position 2
PhD/Post-doc position in Molecular Biology, Neurobiology or related field
Responsibilities:
– Develop and execute cell culture assays to dissect molecular pathways of neurodegeneration in relevant in vitro disease models.
– Perform in vivo experiments on animal models of neurodegenerative diseases.
– Perform flow cytometry and advanced immunohistochemistry methods to analyze brain cell populations.
– Pharmacological studies aimed at validating target candidates using in vitro and in vivo models.
Qualifications:
– MSc/PhD in Molecular Biology, Biotechnology, Neurobiology or related field.
– Experience with Flow Cytometry, Immunohistochemistry, Confocal Microscopy.
– Understanding the molecular mechanisms underlying neurodegenerative conditions is advantageous.
– Experienced in library preparation for single-cell genomics is advantageous.
– Possession of certificates enabling animal experiments is advantageous.
Position 3
PhD/Post-doc position in Molecular Biology, Neurobiology or related field
Responsibilities:
– Conduct formal validation of the new biomarker in a large cohort of ALS patients and disease controls, aiming to define its prognostic and/or monitoring value.
– Data Managing.
– Maintain accurate records.
– Contribute to Statistical Plan and Statistical Analysis
Qualifications:
– Degree in Biology or Biotechnology
– Experience with ELISA assay.
– Experience with Microsoft Office and statistical
software packages
All positions also require:
– Experience with data visualization and scientific writing.
– Ability to work independently and collaboratively in a multidisciplinary team environment.
– Excellent communication skills in English, both written and oral.
– Experience in publishing scientific papers in English-language peer-reviewed journals is a plus.
– Prepare research findings for publication in scientific journals and present results at conferences.
We offer 12-month full-time position(s) with the possibility of renewal up to two-years. The salary will be commensurate to the level of seniority and previous expertise and location.